As people grow older and nutrients, sunlight, influence of environmental factors, human synthesis of hyaluronic acid (Restylane) decreasing capacity HA, hyaluronic acid in the skin (hyaluronic acid) may decrease the content of HA, in the embryonic stages of hyaluronic acid in the body (hyaluronic acid) HA the highest decrease after birth. When 20 year old body's hyaluronic acid (Restylane) relative content positioning 100% HA, 30, 50, 60 years old respectively, and 65%, and 25%. When hyaluronic acid in the skin (hyaluronic acid) HA content falls below a certain level, the layer of skin moisture content decreases, causing aging stratum corneum, skin becomes rough, wrinkles, loss of elasticity, is aging, this phenomenon generally occurs after the age of 25. This is the gap between older people and children's skin is one of the main reasons. While hyaluronic acid in the skin (hyaluronic acid) HA damage associated with UV, so long engaged in field operations, Highland life, outdoors than an indoor staff of the skin is rough.

Double-blind human clinical trials show that after oral administration of 4 hour, hyaluronic acid content in the blood significantly increased peak 12-hour, 70 times higher than the control group. Even served 7 days to reach stable concentration.