The present invention provides a method for granulation of cross-linked sodium hyaluronate gel. It is under the sealing conditions, input the cross-linked sodium hyaluronate gel in the container into the segmentation head through aerodynamic force, through inlet flange and stator center feeding hole in succession, enter into the gap between the stator and the rotor, through the relative rotation of the stator and rotor, and then flow out of the split head through the outlet flange, granulating complete. The whole division head is cooled by the cooling water circulation system. At the same time, as the rotor is fixed on the spindle of the speed regulating motor, the relative rotation speed of the stator and the rotor can be adjusted. The size of the gap between the stator and the rotor can be realized by changing the different combinations.