AFP is a glycoprotein with a mol wt of 65-70 kDa. It has approx. 4% carbohydrates. During fetal development, Alpha- Fetoprotein (AFP) is secreted at high levels and then drops to very low levels in adult life. AFP reappears in serum at high levels in malignant diseases of hepatocellular, testicular, nonseminomatosus origin, and occasionally other entodermal origin. AFP may be slightly elevated or persisted in patients with large hepatic metastases or viral hepatitis. AFP measurement is widely accepted as tumor marker and for monitoring the therapeutic effectiveness of hepatocellular and other cancer.
Test the concentration of serum AFP in vitro.